Gluten Sensitivity by Carlo Catassi

Non-celiac gluten sensitivity (NCGS) is a syndrome characterized by intestinal and extraintestinal symptoms related to the ingestion of gluten-containing food in subjects who are not affected by either celiac disease (CD) or wheat allergy Published online: November 26, 2015 Prof. Carlo Catassi Via F Corridoni 11 IT–60123 Ancona (Italy) E-Mail c.catassi @ univpm.it © 2015 S. Karger AG, Basel 0250–6807/15/0676–0016$39.50/0 www.karger.com/anm Key Messages • Non-celiac gluten sensitivity (NCGS) is a syndrome characterized by intestinal and extraintestinal symptoms related to the ingestion of glutencontaining food in subjects who are not affected by either celiac disease (CD) or wheat allergy. • Indirect evidence suggests that NCGS is more common than CD, the latter affecting around 1% of the general population. • The diagnosis of NCGS is based on establishing a clear-cut cause-effect relationship between the ingestion of gluten and the appearance of symptoms by a standardized double-blind, placebo-controlled